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Generalized Absence Seizures

MedGen UID:
1384814
•Concept ID:
C4505436
•
Disease or Syndrome
Synonyms: Absence Seizure, Generalized; Absence Seizures, Generalized; Generalized Absence Seizure; Seizure, Generalized Absence

Professional guidelines

PubMed

Sodium valproate in the treatment of the intractable childhood epileptic.
Keene DL, Metrakos K, Watters GV, Sherwin A
Can J Neurol Sci 1982 Aug;9(3):307-11. doi: 10.1017/s0317167100044127. PMID: 6811123

Recent clinical studies

Etiology

The first line of therapy in a girl with juvenile myoclonic epilepsy: should it be valproate or a new agent?
Montouris G, Abou-Khalil B
Epilepsia 2009 Sep;50 Suppl 8:16-20. doi: 10.1111/j.1528-1167.2009.02230.x. PMID: 19702728
Utility of daily supervised hyperventilation during long-term video-EEG monitoring.
Arain AM, Arbogast PG, Abou-Khalil BW
J Clin Neurophysiol 2009 Feb;26(1):17-20. doi: 10.1097/WNP.0b013e3181969032. PMID: 19151614
Pediatric epilepsy syndromes.
Glauser TA
Curr Opin Pediatr 1995 Dec;7(6):640-9. doi: 10.1097/00008480-199512000-00003. PMID: 8776013
Exacerbation of seizures in children by carbamazepine.
Snead OC 3rd, Hosey LC
N Engl J Med 1985 Oct 10;313(15):916-21. doi: 10.1056/NEJM198510103131503. PMID: 3929090
Sodium valproate in the treatment of the intractable childhood epileptic.
Keene DL, Metrakos K, Watters GV, Sherwin A
Can J Neurol Sci 1982 Aug;9(3):307-11. doi: 10.1017/s0317167100044127. PMID: 6811123

Diagnosis

Ambulatory seizure detection.
Bernini A, Dan J, Ryvlin P
Curr Opin Neurol 2024 Apr 1;37(2):99-104. Epub 2024 Feb 7 doi: 10.1097/WCO.0000000000001248. PMID: 38328946
Focal corticothalamic sources during generalized absence seizures: a MEG study.
Tenney JR, Fujiwara H, Horn PS, Jacobson SE, Glauser TA, Rose DF
Epilepsy Res 2013 Sep;106(1-2):113-22. Epub 2013 Jun 10 doi: 10.1016/j.eplepsyres.2013.05.006. PMID: 23764296
The first line of therapy in a girl with juvenile myoclonic epilepsy: should it be valproate or a new agent?
Montouris G, Abou-Khalil B
Epilepsia 2009 Sep;50 Suppl 8:16-20. doi: 10.1111/j.1528-1167.2009.02230.x. PMID: 19702728
Indications for network regularization during absence seizures: weighted and unweighted graph theoretical analyses.
Ponten SC, Douw L, Bartolomei F, Reijneveld JC, Stam CJ
Exp Neurol 2009 May;217(1):197-204. Epub 2009 Feb 13 doi: 10.1016/j.expneurol.2009.02.001. PMID: 19232346
Pediatric epilepsy syndromes.
Glauser TA
Curr Opin Pediatr 1995 Dec;7(6):640-9. doi: 10.1097/00008480-199512000-00003. PMID: 8776013

Therapy

The first line of therapy in a girl with juvenile myoclonic epilepsy: should it be valproate or a new agent?
Montouris G, Abou-Khalil B
Epilepsia 2009 Sep;50 Suppl 8:16-20. doi: 10.1111/j.1528-1167.2009.02230.x. PMID: 19702728
Indications for network regularization during absence seizures: weighted and unweighted graph theoretical analyses.
Ponten SC, Douw L, Bartolomei F, Reijneveld JC, Stam CJ
Exp Neurol 2009 May;217(1):197-204. Epub 2009 Feb 13 doi: 10.1016/j.expneurol.2009.02.001. PMID: 19232346
Lupus anticoagulant induced by the combination of valproate and lamotrigine.
Echaniz-Laguna A, Thiriaux A, Ruolt-Olivesi I, Marescaux C, Hirsch E
Epilepsia 1999 Nov;40(11):1661-3. doi: 10.1111/j.1528-1157.1999.tb02054.x. PMID: 10565597
Anticonvulsant drugs: mechanisms of action.
Macdonald RL, McLean MJ
Adv Neurol 1986;44:713-36. PMID: 2871724
Exacerbation of seizures in children by carbamazepine.
Snead OC 3rd, Hosey LC
N Engl J Med 1985 Oct 10;313(15):916-21. doi: 10.1056/NEJM198510103131503. PMID: 3929090

Prognosis

Unified analysis of global and focal aspects of absence epilepsy via neural field theory of the corticothalamic system.
Yang DP, Robinson PA
Phys Rev E 2019 Sep;100(3-1):032405. doi: 10.1103/PhysRevE.100.032405. PMID: 31639915
Indications for network regularization during absence seizures: weighted and unweighted graph theoretical analyses.
Ponten SC, Douw L, Bartolomei F, Reijneveld JC, Stam CJ
Exp Neurol 2009 May;217(1):197-204. Epub 2009 Feb 13 doi: 10.1016/j.expneurol.2009.02.001. PMID: 19232346
Generalized absence seizures with 10-15 Hz fast discharges.
Fakhoury T, Abou-Khalil B
Clin Neurophysiol 1999 Jun;110(6):1029-35. doi: 10.1016/s1388-2457(99)00028-0. PMID: 10402089
Exacerbation of seizures in children by carbamazepine.
Snead OC 3rd, Hosey LC
N Engl J Med 1985 Oct 10;313(15):916-21. doi: 10.1056/NEJM198510103131503. PMID: 3929090

Clinical prediction guides

Spike-and-Wave Discharges Are Not Pathological Sleep Spindles, Network-Level Aspects of Age-Dependent Absence Seizure Development in Rats.
Kozák G, Földi T, Berényi A
eNeuro 2020 Jan/Feb;7(1) Epub 2020 Jan 3 doi: 10.1523/ENEURO.0253-19.2019. PMID: 31862790Free PMC Article
Unified analysis of global and focal aspects of absence epilepsy via neural field theory of the corticothalamic system.
Yang DP, Robinson PA
Phys Rev E 2019 Sep;100(3-1):032405. doi: 10.1103/PhysRevE.100.032405. PMID: 31639915
Indications for network regularization during absence seizures: weighted and unweighted graph theoretical analyses.
Ponten SC, Douw L, Bartolomei F, Reijneveld JC, Stam CJ
Exp Neurol 2009 May;217(1):197-204. Epub 2009 Feb 13 doi: 10.1016/j.expneurol.2009.02.001. PMID: 19232346
Spike-and-wave discharges of absence seizures as a transformation of sleep spindles: the continuing development of a hypothesis.
Kostopoulos GK
Clin Neurophysiol 2000 Sep;111 Suppl 2:S27-38. doi: 10.1016/s1388-2457(00)00399-0. PMID: 10996552
Exacerbation of seizures in children by carbamazepine.
Snead OC 3rd, Hosey LC
N Engl J Med 1985 Oct 10;313(15):916-21. doi: 10.1056/NEJM198510103131503. PMID: 3929090

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